Cannabis sativa was grown widely in the late Middle Ages and beyond, though not for its narcotic properties. Most cannabis [hemp] was used for rope-making, while commoners sometimes used young plants, seeds and pressed oil for food. Medieval and early modern physicians were aware that eating large amounts of cannabis-based foods could induce delirium or euphoria.
Writing around 1551, the Hungarian physician Paulus Kyr urged caution when nibbling on cannabis:
“Cannabis seeds are bad for the head if eaten in great quantity. [They] create foul humours and dry up the genital seed. They are difficult to digest, but are not harmful if crushed with vinegar and honey.”